A “loopy” discovery in bacteria is raising fundamental questions about the makeup of our own genome. And revealing a potential wellspring of material for new genetic therapies.
Researchers at Columbia University College of Dental Medicine have engineered exosomes to carry CRISPR, significantly enhancing the delivery of genome editing components to specific cells and tissues.
Including BRCA1 testing with prenatal carrier screening could identify people at risk of breast, ovarian, and pancreatic cancer at a time when cancer screening could save their lives.
Columbia genome engineers are designing a CRISPR-based gene therapy with potential to prevent blindness in anyone with retinitis pigmentosa, a condition caused by more than 80 different genes.
Many Black Americans thought to have a high risk of developing kidney disease possess a genetic variant that eradicates the extra risk, a new study from Columbia researchers has found.
The genetic changes that made it possible for humans to walk upright have been uncovered in a study that also shows how slight variations in skeletal proportions are linked to arthritis.
Scientists from around the world attended a symposium at Columbia to celebrate the 80th birthday of Tom Maniatis and his contributions to the field of molecular biology.
In the GUARDIAN study, the genomes of newborns are being scanned to identify children who have one of hundreds of treatable and preventable rare genetic conditions before symptoms emerge.
In children with certain autism mutations, the diversity and severity of symptoms are often related to the identity and properties of gene units, called exons, targeted by the mutations.
The most detailed analysis to date of CRISPR genome editing in human embryos finds a significant risk of chromosomal abnormalities when using the technique at the earliest stage of human development.
Columbia researchers have uncovered an array of new genes that cause stillbirth, significantly increasing the understanding of the genetic foundations of a common, but little studied, condition.