Analysis of 1.6 million brain cells from older adults has captured the cellular changes that occur in Alzheimer’s early stages, revealing potential new targets and routes for prevention.
Columbia neuroscientists have identified a genetic mutation that fends off Alzheimer's in people at high risk and could lead to a new way to protect people from the disease.
ADScreen, a speech-processing algorithm developed at Columbia Nursing, is now being tested in a clinical trial to see if it can help health care workers identify patients with Alzheimer's earlier.
African-Americans with Alzheimer’s disease were slightly more likely to have one gene, ABCA7, that is thought to confer risk for the disease. CUMC's Dr. Richard Mayeux led the study.
The largest genome-wide search for Alzheimer’s genes in African-Americans has found that African-Americans with a variant of the ABCA7 gene have almost double the risk of developing late-onset Alzheimer’s disease.
CUMC's Dr. Eric Kandel (2000 Nobel Laureate) said the project may lead to an understanding of "who we are as human beings and how we function and how these terrible diseases arise, and what we might be able to do address them more effectively."
The virus that causes cold sores, along with other viral or bacterial infections, may be associated with cognitive problems; a new study from CUMC's Mira Katan and Mitch Elkind.
More symptoms of depression and lower cognitive status are independently associated with a more rapid decline in the ability to handle tasks of everyday living, according to a study by CUMC researchers.
Depression appears to be associated with mild cognitive impairment and an increased risk of dementia; José A. Luchsinger, MD, MPH was senior author of the study, published in the Archives of Neurology.