Researchers Use Adult Stem Cells To Create Soft Tissue
$2.5 Million NIH Grant to Support Stem Cell Research; Potential for Facial and Breast Reconstruction
NEW YORK, June 28, 2007 – Researchers from Columbia University Medical Center received a $2.5 million grant from the National Institute of Biomedical Imaging and Bioengineering to use stem cells to engineer soft tissue, developing a process that should ultimately allow scientists to use a patient’s own stem cells to develop tissue for facial reconstruction following disfiguring injuries from war, cancer surgery or accidents.
Jeremy Mao, D.D.S, Ph.D. The Columbia research team, led by Jeremy Mao, D.D.S., Ph.D., associate professor of dental medicine, aims to create long-lasting soft tissue implants from mesenchymal stem cells harvested from the patient’s own bone marrow or adipose tissue. Mesenchymal stem cells can differentiate into bone, fat, cartilage and other types of cells.
“Our research has shown that mesenchymal stem cells can create tissue that is biocompatible with the host and that the continuous generation of these cells can replenished the implant to reduce shrinkage,” said Dr. Mao.
Currently, surgeons often graft from the patient’s own tissue, which creates additional wounds. Grafted cells also fail to stay alive, causing implants to shrink up to 70 percent and lose their shape and volume. Attempts have also been made to use fat cells left over after liposuction, but those cells also have a limited lifespan.
The Columbia team of biologists, biomedical engineers, biomaterial scientists, imaging experts and surgeons has shown that human mesenchymal stem cells can create long-lasting implants in mice. The implant is created by placing the stem cells into an FDA-approved scaffold that mimics the conditions needed to turn stem cells into fat cells. Because stem cells have the ability to replicate and differentiate, they can regenerate the soft tissue, keeping the implant from shrinking. In mice, these cells have successfully created fat cells that could be implanted and retained their size and shape for at least a month.
Because the implants can be molded into any size or shape, they could also be used for breast reconstruction.
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Columbia University Medical Center provides international leadership in pre-clinical and clinical research, in medical and health sciences education, and in patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, nurses, dentists, and public health professionals at the College of Physicians & Surgeons, the College of Dental Medicine, the School of Nursing, the Mailman School of Public Health, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions.