The Herbert and Florence Irving Institute for Cancer Dynamics will continue its seminar series on the topic of mathematical sciences underpinning cancer research. The monthly seminars take place on the second Wednesday of the month, 2:00-3:00 PM EST. The presentations are open to the Columbia community (in person and online) and to researchers outside Columbia (via Zoom).
On Wednesday, May 14th (2:00 PM ET), IICD welcomes Elaine Fuchs, Rebecca C. Lancefield Professor, The Rockefeller University and Investigator, Howard Hughes Medical Institute. Seminar hosted by Elham Azizi. The seminar will take place in person in Schermerhorn Hall 603 (Morningside Heights campus). If you wish to attend the seminar remotely, please register using the following link: https://columbiauniversity.zoom.us/meeting/register/tJEqcOuorzojE9VNroPM5DPQ6P1t350y_b7E
Title: Tissue Stem Cells: Coping With Stress and Cancer
Abstract: At the interface of our body and the outside world, our epidermis forms the skin’s barrier that keeps pathogens out. As such it must confront mechanical stress, pollutants, noxious chemicals and pathogens. My laboratory focuses on the long-lived skin stem cells that replenish and repair the epidermis and its appendages (hair follicles, sweat and oil glands). After decades of research characterizing these stem cells and learning how they interact with their local tissue microenvironments (‘niches’) to achieve these tasks, we have turned to how these stem cells cope with the stresses of the external environment and how their malfunction leads to chronic inflammation and non-melanoma skin cancers. We use high throughput genetic and genomic approaches to dissect how changes in the skin’s external environment influence the behavior of the stem cells and their interactions with immune and other cell types of the skin. In doing so, we’ve learned that skin stem cells acquire and recall memories of experiences such as inflammation that happened long ago. This ability has profound implications for body health and fitness not only in beneficial but also maladaptive ways, particularly cancer.
Bio: Elaine Fuchs is renowned for her research in skin biology, its stem cells and associated disorders, including cancers and inflammation. She is an Investigator of the Howard Hughes Medical Institute and has published >380 manuscripts. She received her Ph.D. from Princeton in Biochemistry, her postdoctorate in Cell Biology at MIT, and has been on the faculty, first at University of Chicago and now Rockefeller University. Her awards include the National Medal of Science, L’Oreal-UNESCO Award, International Society for Stem Cell Research’s Innovation Award, the Gairdner International Award and the Franklin Medal. Fuchs holds membership in the National Academy of Sciences, National Academy of Medicine, American Philosophical Society, Pontifical Academy of Sciences, and the Royal Society. She is an inaugural member of the Academy of the American Association for Cancer Research, and now serves as its President.
If you would like to meet one-on-one (possibility via zoom) or attend the lunch or dinner with the speaker, please contact the event organizer.